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KMID : 0387720150260030309
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Korean Journal of Blood Transfusion
2015 Volume.26 No. 3 p.309 ~ p.315
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A Case Report of Transfusion-Related Acute Lung Injury Induced in the Patient with HLA Antibody after Fresh Frozen Plasma Transfusion
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장기설:Chang Ki-Sul
전대원:Jun Dae-Won/김영일:Kim Young-Il/오현우:Oh Hyun-Woo/강민구:Kang Min-Ku/이정훈:Lee Jung-Hoon/문인태:Moon In-Tae
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Abstract
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Development of transfusion-related acute lung injury (TRALI), a non-cardiogenic pulmonary edema, after blood transfusion, is a rare but potentially leading cause of mortality from blood transfusion. We report on a case of TRALI in a 51-year male with acute calculous cholecystitis and liver cirrhosis. As preoperative treatment, he was given ten units of fresh frozen plasma (FFP) for 3 days before the operation. During the transfusion of the 10th unit of FFP, he experienced a sudden onset of hemoptysis, tachypnea, tachycardia, and cyanosis. Bilateral pulmonary infiltration not observed on the chest X-ray at the visit was newly developed. There was no evidence of volume overload but severe hypoxemia. Blood transfusion was stopped and he recovered fully after 8 days of oxygen therapy through a nasal cannula. Although HLA and HNA antibodies were not detected in the donor’s blood, HLA antibodies (A2, B57, B58) were detected in the patient’s blood. We reported this meaningful case of TRALI that occurred after transfusion of only fresh frozen plasma which did not contain human leukocyte antibody in a patient with HLA antibody.
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KEYWORD
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Transfusion-related acute lung injury (TRALI), Fresh frozen plasma (FFP), Anti-HLA antibody
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